Micky van de Ven Double Halts Everton's Run at Brand New Stadium
The Dutch defender became the first defender to net two goals in a English top-flight game for Spurs since Jan Vertonghen in spring 2013.
At a glance
The Spurs defender heads home twice in opening period
Everton's defender has equalizer disallowed after VAR review
Pape Matar Sarr nets third in 89th minute
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham extended their winning streak in away games in the top division and handed Everton their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their new ground at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader Van de Ven struck twice from corners in the first half to place their impressive record at risk, and they were unable to mount a comeback before the midfielder - set up by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the scores five minutes after Van de Ven's first goal, directing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of chances, while the Italian goalkeeper made a series of excellent saves to guarantee Tottenham went five matches on the road unbeaten in the English top flight.
But the VAR stepped in, advising Craig Pawson to check the goal on the screen and the referee decided that the winger and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
The win elevates the manager's team into third place in the Premier League, five points off local foes and leaders Arsenal.
Everton stay in 14th position and are six points ahead of the relegation zone.
Spurs breakdown: The defender excels in role at each end of the field
After a uninspiring weekday display in the Champions League against the French side, where they mustered a only attempts on target, Frank opted for Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The new arrival was unable to influence the game before being substituted for Richarlison after 60 minutes on the field, but it emerged he proved unnecessary in the end.
Defender Van de Ven converted into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball back across the six-yard box for an unmarked the defender to head home.
And the captain - filling in as skipper in Cristian Romero's unavailability - notched his second in first-half stoppage time as he rose above the England keeper to nod in.
The Dutchman was just as outstanding in defence, combining well with Kevin Danso as the pair handled superbly with the 34 crosses thrown their way by Everton.
Everton analysis: Toffees lacking striker's instinct
Everton's new home had been a happy hunting ground, but it appears the freshness may have faded somewhat and fans headed to the gates after Sarr's third for Tottenham.
The break in the team's unbeaten home run won't be a massive concern for David Moyes, but their attacking woes will be.
Beto and the other striker - the Everton's two recognised centre-forwards - had scored just one league goal between them before Sunday's match.
And they were failed to contribute to that miserable record on a wet and gloomy night on Merseyside.
The striker's performance was epitomized when he opted to bicycle-kick a golden opportunity from close range, despite having room and opportunity to reposition for a more conventional shot that would have challenged the keeper.
Barry, too, failed to influence the game after replacing the starter in the 65th minute.
It was not for a lack of opportunity. Most of the home side's offensive moves came through the winger and the forward, who relentlessly whipped dangerous crosses into the Spurs box.
What next for both teams?
Everton: The team head to the Stadium of Light in the top flight on Monday, 3 November at 8 PM.
Spurs: Spurs go to St James' Park on late October for their next round League Cup tie against the Magpies.